OSCON has a history of great coverage of Ruby, Perl, and Java stuff. That's great, and I don't want it to go away, but it might be a little lopsided. Some stuff I'd love to see more of, that seems a little underrepresented in past OSCON's:

• Google Android
• GNOME
• Flex / ActionScript
• Virtualization
• Wordpress and Serendipity
• Drupal and Joomla
• operations stuff
• configuration management (puppet, cfengine)
• Web Usability stuff - eg Steve Krug
• Javascript libraries

Adding to the wish list...

• +1 on virtualization
• Multicore programming
• identi.ca/Laconica

More: Geospatial, ie mapping!

* +1 for geo